Studies over the past two decades have identified ceramide as a multifunctional central
molecule in the sphingolipid biosynthetic pathway. Given its diverse tumor suppressive …

Ceramide and sphingomyelin (SM) are major components of the double membrane-bound
sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes …

Sphingolipids are most prominently expressed in the plasma membrane, but recent studies
have pointed to important signaling and regulatory roles in the nucleus. The most abundant …

Lipid mediators are important endogenous regulators of neural cell proliferation,
differentiation, oxidative stress, inflammation, and apoptosis. They originate from enzymic …

Although the role of 1α, 25‐dihydroxyvitamin D3 in calcium homeostasis of bone tissue is
clear, evidence of the involvement of vitamin D3 in the central nervous system functions is …

It is known that nuclear lipids play a role in proliferation, differentiation, and apoptotic
process. Cellular nuclei contain high levels of phosphatidylcholine and sphingomyelin …

Forty years ago, the term “apoptosis” was introduced to describe a form of programmed cell
death. Key players that mediate apoptosis at the molecular level such as caspases, death …

Most of the previous work on the sphingolipid ceramide has been devoted to its function as
an apoptosis inducer. Recent studies, however, have shown that in stem cells, ceramide has …

Phospholipids, sphingolipids, and cholesterol are integral components of eukaryotic cell
organelles, including the nucleus. Recent evidence shows characteristic features of nuclear …

The intracellular routes of sphingolipid trafficking are related to the compartmentalized
nature of sphingolipid metabolism, with synthesis beginning in the endoplasmic reticulum …