Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

We report a method of cancer immunotherapy using an attenuated Salmonella typhimurium
strain engineered to secrete Vibrio vulnificus flagellin B (FlaB) in tumor tissues. Engineered …

Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

It was already clinically apparent 150 years ago that bacterial therapy could alleviate
diseases. Recently, a burgeoning number of researchers have been using bacterial …

Targeted therapy and immunotherapy have brought hopes for precision cancer treatment.
However, complex physiological barriers and tumor immunosuppression result in poor …

Although strains of attenuated Salmonella typhimurium and wild-type Escherichia coli show
similar tumor-targeting capacities, only S. typhimurium significantly suppresses tumor growth …

There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

Bacteria have been investigated as anti-tumor therapeutic agents for more than a century,
since Coley first observed successful curing of a patient with inoperable cancer by injection …

Introduction Cell-penetrating peptide (CPP) technologies represent an important strategy to
address drug delivery to specific intracellular compartments by covalent conjugation to …