The RecA-directed recombination pathway of natural transformation initiates at chromosomal replication forks in the pneumococcus

CHG Johnston, R Hope, AL Soulet… - Proceedings of the …, 2023 - National Acad Sciences
Homologous recombination (HR) is a crucial mechanism of DNA strand exchange that
promotes genetic repair and diversity in all kingdoms of life. Bacterial HR is driven by the …

Multiple mechanisms for overcoming lethal over‐initiation of DNA replication

ME Anderson, JL Smith… - Molecular Microbiology, 2022 - Wiley Online Library
DNA replication is highly regulated and primarily controlled at the step of initiation. In
bacteria, the replication initiator DnaA and the origin of replication oriC are the primary …

[PDF][PDF] Anatomy of the pneumococcal nucleoid

R van Raaphorst - core.ac.uk
The pneumococcus resides in the nasopharynx of over half of the population of healthy
children under four and about 10% of the adult population (Regev-Yochay et al., 2004; …

Anatomy of the pneumococcal nucleoid: Visualizing replication, chromosome segregation and chromosome condensation dynamics in Streptococcus pneumoniae

R van Raaphorst - 2020 - research.rug.nl
The pneumococcus is a bacterium that lives in the upper part of the throat behind the nose of
many children and adults. In most cases it lives there harmlessly, but sometimes, it can move …