Genetically attenuated microorganisms, including pathogenic and commensal bacteria, can
be engineered to carry and deliver heterologous antigens to elicit host immunity against …

Currently licensed pneumococcal vaccines are based on the generation of antibodies to the
pneumococcal polysaccharide, of which there are more than 90 different types. While these …

Recombinant attenuated Salmonella vaccine (RASV) vectors producing recombinant gene-
encoded protective antigens should have special traits. These features ensure that the …

Vaccines afford a better and more cost-effective approach to combatting infectious diseases
than continued reliance on antibiotics or antiviral or antiparasite drugs in the current era of …

Attenuated Salmonella vaccines can be administered orally to deliver recombinant antigens
to mucosal surfaces inducing a protective immune response against a variety of targeted …

Along with surging threats and antibiotic resistance of Pseudomonas aeruginosa in health
care settings, it is imperative to develop effective vaccines against P. aeruginosa infection. In …

To develop an effective Pseudomonas aeruginosa outer-membrane-vesicle (OMV) vaccine,
we eliminated multiple virulence factors from a wild-type (WT) P. aeruginosa strain, PA103 …

Streptococcus pneumoniae still causes severe morbidity and mortality worldwide, especially
in young children and the elderly. Much effort has been dedicated to developing protein …

Minicircle DNA (mcDNA), which contains only the necessary components for eukaryotic
expression and is thus smaller than traditional plasmids, has been designed for application …

A universal vaccine protecting against multiple serotypes of Streptococcus suis is urgently
needed to improve animal welfare and reduce the consumption of antibiotics. In this study, a …