Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Roles of tau protein in health and disease
Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …
Alzheimer's disease failed clinical trials
S Asher, R Priefer - Life sciences, 2022 - Elsevier
Alzheimer's disease is a progressive neurodegenerative disease typically presenting with
symptoms of memory loss and cognitive decline. Existing theories for the causation of this …
symptoms of memory loss and cognitive decline. Existing theories for the causation of this …
Periodontal microorganisms and Alzheimer disease–A causative relationship?
G Jungbauer, A Stähli, X Zhu… - Periodontology …, 2022 - Wiley Online Library
In the initiation or exacerbation of Alzheimer disease, the dissemination of oral
microorganisms into the brain tissue or the low‐level systemic inflammation have been …
microorganisms into the brain tissue or the low‐level systemic inflammation have been …
Role of tau protein in Alzheimer's disease: The prime pathological player
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
Autophagy and Alzheimer's disease: from molecular mechanisms to therapeutic implications
MS Uddin, A Stachowiak, AA Mamun… - Frontiers in aging …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
[HTML][HTML] α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice
YH Zhang, DW Wang, SF Xu, S Zhang, YG Fan… - Redox Biology, 2018 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) …
characterized by neurofibrillary tangles (NFTs) composed of Tau protein. α-Lipoic acid (LA) …
Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century
Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …
widely used in Southeast Asia, China and India in food preparation and for medicinal …
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various
neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of …
neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of …