The tumor microenvironment is one of the important drivers of tumor development. Cancer-
associated fibroblasts (CAFs) are a major component of the tumor stroma and actively …

A lot of effort has been done to study how cancer cells react to low-oxygen tension, a
condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor …

Formation of lymphatic metastasis is the initial step of generalized spreading of tumor cells
and predicts poor clinical prognosis. Lymphatic vessels generally arise within the …

Lymphatic invasion is a commonly reported histopathological finding in the assessment of
primary tumors. In some studies, it has been found to be a predictor of shorter disease-free …

The lymphatic system is composed of a vascular network of thin-walled capillaries that drain
protein-rich lymph from the extracellular spaces within most organs. A continuous single-cell …

Objective: The aim of this study was to investigate the prognostic relevance of
lymphangiogenesis and lymphovascular invasion in a large cohort of breast cancer patients …

Angiogenesis and lymphangiogenesis are essential for breast cancer progression and are
regulated by vascular endothelial growth factors (VEGF). To determine clinical and …

Purpose. The normal cornea is devoid of blood and lymphatic vessels but can become
vascularized secondary to a variety of corneal diseases and surgical manipulations …

Traditionally, tumor-associated lymphatic vessels have been regarded as passive by-
standers, serving simply as a drainage system for interstitial fluid generated within the tumor …

Previous studies have shown that tumors can induce angiogenesis and lymphangiogenesis,
which plays an important role in promoting hematogenous and lymphogenous spread. In …