T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient
prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined.
Here we demonstrate that impaired actin polymerization results in CD4+ and CD8+ T cells …

Cytotoxic T lymphocytes are effector CD8+ T cells that eradicate infected and malignant
cells. Here we show that the transcription factor NFATc1 controls the cytotoxicity of mouse …

T cell activation and function require a structured engagement of antigen-presenting cells.
These cell contacts are characterized by two distinct dynamics in vivo: transient contacts …

Cytoskeleton plays a significant role in the shape change, migration, movement, adhesion,
cytokinesis, and phagocytosis of tumor cells. In clinical practice, some anti-cancer drugs …

Antigen-specific immunity requires regulated trafficking of T cells in and out of diverse
tissues in order to orchestrate lymphocyte development, immune surveillance, responses …

Triggering of the T cell receptor (TCR) integrates both binding kinetics and mechanical
forces. To understand the contribution of the T cell cytoskeleton to these forces, we triggered …