The impact of selenium deficiency on cardiovascular function

BK Shimada, N Alfulaij, LA Seale - International journal of molecular …, 2021 - mdpi.com
Selenium (Se) is an essential trace element that is necessary for various metabolic
processes, including protection against oxidative stress, and proper cardiovascular function …

The role of selenium in atherosclerosis development, progression, prevention and treatment

SA Dabravolski, VN Sukhorukov, AA Melnichenko… - Biomedicines, 2023 - mdpi.com
Selenium is an essential trace element that is essential for various metabolic processes,
protection from oxidative stress and proper functioning of the cardiovascular system. Se …

Oxidative stress-induced skeletal muscle injury involves in NF-κB/p53-activated immunosuppression and apoptosis response in copper (II) or/and arsenite-exposed …

H Zhao, Y Wang, Y Shao, J Liu, S Wang, M Xing - Chemosphere, 2018 - Elsevier
The adverse effects of environmental toxicants such as copper and arsenic occur due to the
generation of reactive oxygen species. Recent study also reported that both copper (Cu) and …

[HTML][HTML] miR-200a-5p regulates myocardial necroptosis induced by Se deficiency via targeting RNF11

T Yang, C Cao, J Yang, T Liu, XG Lei, Z Zhang, S Xu - Redox biology, 2018 - Elsevier
Necroptosis has been discovered as a new paradigm of cell death and may play a key role
in heart disease and selenium (Se) deficiency. Hence, we detected the specific microRNA …

Targeting the miR-122/PKM2 autophagy axis relieves arsenic stress

Y Wang, H Zhao, M Guo, D Fei, L Zhang… - Journal of hazardous …, 2020 - Elsevier
Arsenic (As) is a natural hepatotoxicity inducer that is found ubiquitously in foods and
environmental media. We found that arsenite exposure elicits autophagy in vivo and vitro …

Trehalose prevents cadmium-induced hepatotoxicity by blocking Nrf2 pathway, restoring autophagy and inhibiting apoptosis

ZG Gong, XY Wang, JH Wang, RF Fan… - Journal of inorganic …, 2019 - Elsevier
Cadmium (Cd) is a ubiquitously distributed environmental pollutant that is highly toxic to
liver. Trehalose (Tr), a novel autophagy activator, has been shown to exert cytoprotective …

[HTML][HTML] Quercetin alleviates Cadmium-induced autophagy inhibition via TFEB-dependent lysosomal restoration in primary proximal tubular cells

Y Zhao, ZF Li, D Zhang, ZY Wang, L Wang - … and environmental safety, 2021 - Elsevier
Autophagy dysregulation plays a pivotal role in cadmium (Cd)-induced nephrotoxicity.
Quercetin (Qu), a flavonoid antioxidant with autophagy-enhancing effect, has protective …

[HTML][HTML] Selenium deficiency dysregulates one-carbon metabolism in nutritional muscular dystrophy of chicks

JC Yang, YX Huang, H Sun, M Liu, L Zhao… - The Journal of Nutrition, 2023 - Elsevier
Background Nutritional muscular dystrophy (NMD) in animals is induced by dietary selenium
(Se) deficiency. Objectives This study was conducted to explore the underlying mechanism …

[HTML][HTML] Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine

Y Zheng, H Guan, J Yang, J Cai, Q Liu, Z Zhang - Animal Nutrition, 2021 - Elsevier
Selenium (Se) deficiency can seriously affect the small intestine of swine, and cause
diarrhea in swine. However, the specific mechanism of Se deficiency-induced swine …

Selenium deficiency induces spleen pathological changes in pigs by decreasing selenoprotein expression, evoking oxidative stress, and activating inflammation and …

S Li, W Sun, K Zhang, J Zhu, X Jia, X Guo… - Journal of Animal …, 2021 - Springer
Background The immune system is one aspect of health that is affected by dietary selenium
(Se) levels and selenoprotein expression. Spleen is an important immune organ of the body …