The rate of single-nucleotide polymorphism varies substantially across the human genome
and fundamentally influences evolution and incidence of genetic disease. Previous studies …

A detailed understanding of the genome-wide variability of single-nucleotide germline
mutation rates is essential to studying human genome evolution. Here, we use~ 36 million …

Background SARS-CoV-2 is a novel coronavirus that causes COVID-19 infection, with a
closest known relative found in bats. For this virus, hundreds of genomes have been …

We aimed to investigate the epidemiological determinants, clinical features, and genetic
pattern of FOP in our country by evaluating the entire population of patients identified …

Background The modern evolutionary synthesis leaves unresolved some of the most
fundamental, long-standing questions in evolutionary biology: What is the role of sex in …

Mutation rate varies between sites in the genome. Part of this variation can be explained by
well-recognized short nucleotide contexts, but a large component of this variation remains …

Background CpG dinucleotides are extensively underrepresented in mammalian genomes.
It is widely accepted that genome-wide CpG depletion is predominantly caused by an …

DNA damage in somatic cells originates from both environmental and endogenous sources,
giving rise to mutations through multiple mechanisms. When these mutations affect the …

Amino acids show apparent propensities toward their neighbors. In addition to preferences
of amino acids for their neighborhood context, amino acid substitutions are also considered …

Substitution rates strongly depend on their nucleotide context. One of the most studied
examples is the excess of C> T mutations in the CG context in various groups of organisms …