Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …
single-cell technologies have revealed that these reactive microglia were with high spatial …
Alzheimer's and Parkinson's disease therapies in the clinic
P Chopade, N Chopade, Z Zhao… - Bioengineering & …, 2023 - Wiley Online Library
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …
neurodegenerative diseases, affecting millions and costing billions each year in the United …
Bidirectional microglia–neuron communication in health and disease
Z Szepesi, O Manouchehrian, S Bachiller… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …
Microglia in Alzheimer disease: well-known targets and new opportunities
AL Hemonnot, J Hua, L Ulmann… - Frontiers in aging …, 2019 - frontiersin.org
Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …
in brain development, and physiology during life and aging. Equipped with a variety of …
Apoptotic bodies for advanced drug delivery and therapy
M Zhou, YJ Li, YC Tang, XY Hao, WJ Xu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …
[HTML][HTML] Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …
Increased microglial exosomal miR-124-3p alleviates neurodegeneration and improves cognitive outcome after rmTBI
X Ge, M Guo, T Hu, W Li, S Huang, Z Yin, Y Li, F Chen… - Molecular Therapy, 2020 - cell.com
Repetitive mild traumatic brain injury (rmTBI) is considered to be an important risk factor for
long-term neurodegenerative disorders such as Alzheimer's disease, which is characterized …
long-term neurodegenerative disorders such as Alzheimer's disease, which is characterized …
MicroRNAs in extracellular vesicles: sorting mechanisms, diagnostic value, isolation, and detection technology
D Xu, K Di, B Fan, J Wu, X Gu, Y Sun… - … in Bioengineering and …, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of short, single-stranded, noncoding RNAs, with a length
of about 18–22 nucleotides. Extracellular vesicles (EVs) are derived from cells and play a …
of about 18–22 nucleotides. Extracellular vesicles (EVs) are derived from cells and play a …
Exosomes and their MicroRNA cargo: new players in peripheral nerve regeneration
Peripheral nerve injury is a major clinical problem and often results in a poor functional
recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal …
recovery. Despite obvious clinical need, treatment strategies have been largely suboptimal …
Potential effects of MSC-derived exosomes in neuroplasticity in Alzheimer's disease
EE Reza-Zaldivar, MA Hernández-Sapiéns… - Frontiers in cellular …, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia affecting regions of the
central nervous system that exhibit synaptic plasticity and are involved in higher brain …
central nervous system that exhibit synaptic plasticity and are involved in higher brain …