Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …

Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …

Remyelination failure contributes to axonal loss and progression of disability in multiple
sclerosis. The failed repair process could be due to ongoing toxic neuroinflammation and to …

Since Río-Hortega's description of oligodendrocyte morphologies nearly a century ago,
many studies have observed myelin sheath-length diversity between CNS regions [1–3] …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

▪ Abstract Significant advances have been made in the application of genetics to probe the
functions of basement membrane laminins. These studies have shown that different laminin …

The ternary complex of integrin-linked kinase (ILK), PINCH and parvin functions as a
signalling platform for integrins by interfacing with the actin cytoskeleton and many diverse …

Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization
that enables rapid and efficient nerve conduction within the central nervous system. The …

Cancer development requires the acquisition of several capabilities that include increased
replicative potential, anchorage and growth-factor independence, evasion of apoptosis …