Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease

A Lonardo, LE Adinolfi, P Loria, N Carulli, G Ruggiero… - Gastroenterology, 2004 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) and hepatitis C virus (HCV)-related liver disease
are common in the general population, but their concurrence is 2-to 3-fold higher than would …

Histological assessment of non‐alcoholic fatty liver disease

SG Hübscher - Histopathology, 2006 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is an important complication of the metabolic
syndrome, which is becoming an increasingly common cause of chronic liver disease …

[PDF][PDF] Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis

AD Clouston, EE Powell, MJ Walsh… - …, 2005 - Wiley Online Library
The mechanisms for progressive fibrosis and exacerbation by steatosis in patients with
chronic hepatitis C (HCV) are still unknown. We hypothesized that proliferative blockade in …

[PDF][PDF] Steatosis: co‐factor in other liver diseases

EE Powell, JR Jonsson, AD Clouston - Hepatology, 2005 - Wiley Online Library
The prevalence of fatty liver is rising in association with the global increase in obesity and
type 2 diabetes. In the past, simple steatosis was regarded as benign, but the presence of …

High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C

BL Bressler, M Guindi, G Tomlinson, J Heathcote - Hepatology, 2003 - Elsevier
The aim of this study was to determine if body mass index (BMI) was an independent
predictor of response to antiviral treatment in patients with chronic hepatitis C. A …

Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C

L Fartoux, A Poujol-Robert, J Guechot, D Wendum… - Gut, 2005 - gut.bmj.com
Background: Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin
resistance could be the cause or consequence of steatosis and fibrosis is unknown. The …

Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C

IJ Hickman, AD Clouston, GA Macdonald, DM Purdie… - Gut, 2002 - gut.bmj.com
Background: Steatosis occurs in more than 50% of patients with chronic hepatitis C and is
associated with increased hepatic fibrosis. In many of these patients the pathogenesis of …

Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies

L Castera, C Hezode, F Roudot-Thoraval, A Bastie… - Gut, 2003 - gut.bmj.com
Background and aims: Steatosis, a frequent histological finding in patients with chronic
hepatitis C (CHC), has been suggested to influence liver fibrosis progression. The aim of the …

Contribution of obesity to hepatitis C-related fibrosis progression

V Ortiz, M Berenguer, JM Rayón… - Official journal of the …, 2002 - journals.lww.com
OBJECTIVE: Hepatitis C virus (HCV) disease progression is variable. Identification of factors
predictive of rapid progression is an important goal for improving patient management. The …

Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients

J Westin, H Nordlinder, M Lagging, G Norkrans… - Journal of …, 2002 - Elsevier
Background/Aims: Steatosis is common in patients with hepatitis C virus (HCV) infection. Its
influence on disease progression is only partially understood. The aim of this study was to …