Modern approaches to HLA-haploidentical blood or marrow transplantation

CG Kanakry, EJ Fuchs, L Luznik - Nature reviews Clinical oncology, 2016 - nature.com
Allogeneic blood or bone-marrow transplantation (alloBMT) is a potentially curative
treatment for a variety of haematological malignancies and nonmalignant diseases …

Imatinib mesylate—a new oral targeted therapy

DG Savage, KH Antman - New England Journal of Medicine, 2002 - Mass Medical Soc
This review discusses the development and uses of imatinib mesylate, a protein tyrosine
kinase inhibitor useful in the treatment of chronic myelogenous leukemia and …

Double unrelated umbilical cord blood vs HLA-haploidentical bone marrow transplantation: the BMT CTN 1101 trial

EJ Fuchs, PV O'Donnell, M Eapen… - Blood, The Journal …, 2021 - ashpublications.org
Results of 2 parallel phase 2 trials of transplantation of unrelated umbilical cord blood (UCB)
or bone marrow (BM) from HLA-haploidentical relatives provided equipoise for direct …

Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression

LP Wachsmuth, MT Patterson… - The Journal of …, 2019 - Am Soc Clin Investig
Posttransplantation cyclophosphamide (PTCy) recently has had a marked impact on human
allogeneic hematopoietic cell transplantation (HCT). Yet our understanding of how PTCy …

[HTML][HTML] HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation …

L Luznik, PV O'Donnell, HJ Symons, AR Chen… - Biology of Blood and …, 2008 - Elsevier
We evaluated the safety and efficacy of high-dose, posttransplantation cyclophosphamide
(Cy) to prevent graft rejection and graft-versus-host disease (GVHD) after outpatient …

HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease

J Bolaños-Meade, EJ Fuchs, L Luznik… - Blood, The Journal …, 2012 - ashpublications.org
Allogeneic marrow transplantation can cure sickle cell disease; however, HLA-matched
donors are difficult to find, and the toxicities of myeloablative conditioning are prohibitive for …

Risk-stratified outcomes of nonmyeloablative HLA-haploidentical BMT with high-dose posttransplantation cyclophosphamide

SR McCurdy, JA Kanakry, MM Showel… - Blood, The Journal …, 2015 - ashpublications.org
Related HLA-haploidentical blood or marrow transplantation (BMT) with high-dose
posttransplantation cyclophosphamide (PTCy) is being increasingly used because of its …

Reduced-intensity transplantation for lymphomas using haploidentical related donors versus HLA-matched sibling donors: a Center for International Blood and …

N Ghosh, R Karmali, V Rocha, KW Ahn… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Related donor haploidentical hematopoietic cell transplantation (Haplo-HCT) using
post-transplantation cyclophosphamide (PT-Cy) is increasingly used in patients lacking HLA …

Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age

C Kollman, CWS Howe, C Anasetti… - Blood, The Journal …, 2001 - ashpublications.org
The National Marrow Donor Program (NMDP) maintains a registry of approximately 4 million
volunteer unrelated donors for patients in need of a stem cell transplant. When several …

Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia

MJ Laughlin, M Eapen, P Rubinstein… - New England journal …, 2004 - Mass Medical Soc
Background Data regarding the outcome of cord-blood transplantation in adults are scant,
despite the fact that these grafts are increasingly used in adults. Methods We compared the …