The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …

Successful delivery of drugs and nanomedicine to tumors requires a functional vascular
network, extravasation across the capillary wall, penetration through the extracellular matrix …

Hypoxia occurs in the majority of tumours, promoting angiogenesis, metastasis and
resistance to therapy. Responses to hypoxia are orchestrated in part through activation of …

Tumor cells develop resistance to chemotherapeutic drugs through multiple mechanisms.
Overexpression of efflux transporters is an important source of drug resistance. Efflux …

Tumors are not merely masses of neoplastic cells but complex tissues composed of cellular
and noncellular elements. This review provides recent data on the main components of a …

The microenvironment of solid tumors is a heterogeneous, complex milieu for tumor growth
and survival that includes features such as acidic pH, low nutrient levels, elevated interstitial …

Drug resistance is a major challenge to the effective treatment of cancer. We have
developed two nanoparticle formulations, cationic liposome-polycation-DNA (LPD) and …

Tumor interstitial pressure is a fundamental feature of cancer biology. Elevation in tumor
pressure affects the efficacy of cancer treatment. It causes heterogenous intratumoral …

Tocotrienols are naturally occurring forms of vitamin E based on their structural similarity.
This study focused on investigating anticancer effects of tocotrienols and the mechanisms of …

Interstitial fluid pressure is elevated in virtually all solid malignant tumors as a result of
abnormalities of the vasculature and interstitium. High interstitial fluid pressure is an …