Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …

Imaging technologies are increasingly used to generate high-resolution reference maps of
brain structure and function. Comparing experimentally generated maps to these reference …

Gene expression fundamentally shapes the structural and functional architecture of the
human brain. Open-access transcriptomic datasets like the Allen Human Brain Atlas provide …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …

The psychedelic effects of some plants and fungi have been known and deliberately
exploited by humans for thousands of years. Fungi, particularly mushrooms, are the principal …

Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …