The treatment of long-gap (> 10 mm) peripheral nerve injury (PNI) and spinal cord injury
(SCI) remains a continuous challenge due to limited native tissue regeneration capabilities …

During nervous system development, an extracellular matrix (ECM) plays a pivotal role
through surface topography and microenvironment signals in neurons and neurites …

Noncovalent interactions between cells and environmental cues have been recognized as
fundamental physiological interactions that regulate cell behavior. However, the effects of …

Unlike other tissue types, like epithelial tissue, which consist of cells with a much more
homogeneous structure and function, the nervous tissue spans in a complex multilayer …

Topography of the extracellular environment is now recognized as a major biophysical
regulator of cell behavior and function. The study of the influence of patterned substrates on …

In biological systems, form and function are inherently correlated. Despite this strong
interdependence, the biological effect of curvature has been largely overlooked or …

Engineered 3D neuronal networks are considered a promising approach for repairing the
damaged spinal cord. However, the lack of a technological platform encouraging axonal …

Electrical and/or electromechanical stimulation has been shown to play a significant role in
regenerating various functionalities in soft tissues, such as tendons, muscles, and nerves. In …

Although many details remain still elusive, it became increasingly evident in recent years
that mechanosensing of microenvironmental biophysical cues and subsequent …

Extracellular soluble signals are known to play a critical role in maintaining neuronal
function and homeostasis in the CNS. However, the CNS is also composed of extracellular …