Strains of the Beijing/W genotype family of Mycobacterium tuberculosis have caused large
outbreaks of tuberculosis, sometimes involving multidrug resistance. This genetically highly …

Tuberculosis (TB) was the underlying cause of 1.3 million deaths among human
immunodeficiency virus (HIV)-negative people in 2016, exceeding the global number of …

van Soolingen D (National Institute of Public Health and the Environment, Bilthoven, The
Netherlands). Molecular epidemiology of tuberculosis and other mycobacterial infections …

Objective.—To investigate a multi-institutional outbreak of highly resistant tuberculosis and
evaluate patient outcome. Design.—Epidemiologic investigation of every tuberculosis case …

Objective.—To determine whether isolates ofMycobacterium tuberculosisfrom New York and
elsewhere that are resistant to four or more primary antimicrobial agents and responsible for …

Molecular biology techniques have become increasingly integrated into the practice of
infectious disease epidemiology. The term “molecular epidemiology” routinely appears in …

Inducible nitric oxide synthase (iNOS) plays an important role in host defense. Macrophages
expressing iNOS release the reactive nitrogen intermediates (RNI) nitrite and S …

Murine macrophages effect potent antimycobacterial function via the production of nitric
oxide by the inducible isoform of the enzyme nitric oxide synthase (NOS2). The protective …

Context.—Cases of tuberculosis (TB) in the United States have declined for 4 consecutive
years, but cases among foreign-born persons account for an increasing percentage …

ContextTyping of Mycobacterium tuberculosis could provide a more sensitive means of
identifying outbreaks than use of conventional surveillance techniques alone. Variants of the …