Targeting different phenotypes of macrophages: A potential strategy for natural products to treat inflammatory bone and joint diseases

Y Gao, X Xu, X Zhang - Phytomedicine, 2023 - Elsevier
Background Macrophages, a key class of immune cells, have a dual role in inflammatory
responses, switching between anti-inflammatory M2 and pro-inflammatory M1 subtypes …

[HTML][HTML] Global scientific trends update on macrophage polarization in rheumatoid arthritis: A bibliometric and visualized analysis from 2000 to 2022

J Yuan, T Feng, Y Guo, K Luo, Q Wu, S Yu, H Zhou - Heliyon, 2023 - cell.com
The goal of this work was to use bibliometric analysis to help guide future research on
macrophage polarization in RA. We looked for studies on macrophage polarization in RA …

Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF-κB pathway in rheumatoid arthritis

H Yang, C Liu, X Lin, X Li, S Zeng, Z Gong, Q Xu… - Archives of Biochemistry …, 2024 - Elsevier
Background Rheumatoid arthritis (RA) is currently an autoimmune inflammatory disease
with an unclear pathogenesis. Fibroblast-like synoviocytes (FLSs) have tumor-like …

Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis

JW Chang, YY Lin, CH Tsai, SC Liu, XY He… - Biochemical …, 2023 - Elsevier
Rheumatoid arthritis (RA) is a common autoimmune disease marked by immune cell
activation and chronic inflammation in the synovium accompanied by osteoclast activation …

Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts

Y Zheng, K Wei, P Jiang, J Zhao, Y Shan, Y Shi… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent
synovial inflammation and progressive joint destruction. Macrophages are key effector cells …

[HTML][HTML] Bone marrow adipocytes and lung cancer bone metastasis: unraveling the role of adipokines in the tumor microenvironment

J Li, J Wu, Y Xie, X Yu - Frontiers in Oncology, 2024 - frontiersin.org
Bone is a common site of metastasis for lung cancer. The “seed and soil” hypothesis
suggests that the bone marrow microenvironment (“soil”) may provide a conducive survival …

MCP-1 controls IL-17-promoted monocyte migration and M1 polarization in osteoarthritis

SL Hsieh, SY Yang, CY Lin, XY He, CH Tsai… - International …, 2024 - Elsevier
Osteoarthritis (OA) is a low-grade inflammatory joint illness in which monocytes migrate and
infiltrate synovial tissue, differentiating into the pro-inflammatory M1 macrophage phenotype …

[HTML][HTML] Visfatin Facilitates VEGF-D-Induced Lymphangiogenesis through Activating HIF-1α and Suppressing miR-2277-3p in Human Chondrosarcoma

CY Song, SL Hsieh, SY Yang, CY Lin… - International Journal of …, 2024 - mdpi.com
Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous
tissue and is associated with lung metastases. Lymphangiogenesis plays an essential role …

Hierarchical Microcarriers Loaded with Peptide Dendrimer‐Grafted Methotrexate for Rheumatoid Arthritis Treatment

Y Li, H Zhu, R Liu, Y Zhao, L Sun - Small Science, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is one of the leading causes of disability due to the autoimmune
destruction of synovial joints. Great efforts have been put into developing multifunctional …

NGF facilitates ICAM-1-dependent monocyte adhesion and M1 macrophage polarization in rheumatoid arthritis

CY Lin, KT Lee, YY Lin, CH Tsai, CY Ko… - International …, 2024 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder in which
monocytes adhering to synovial tissue differentiate into the pro-inflammatory M1 …