[HTML][HTML] Monitoring Plasmodium vivax resistance to antimalarials: Persisting challenges and future directions

MU Ferreira, TN de Sousa, GW Rangel… - International Journal for …, 2021 - Elsevier
Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

Plasmodium vivax Biology: Insights Provided by Genomics, Transcriptomics and Proteomics

C Bourgard, L Albrecht, ACAV Kayano… - Frontiers in cellular …, 2018 - frontiersin.org
During the last decade, the vast omics field has revolutionized biological research,
especially the genomics, transcriptomics and proteomics branches, as technological tools …

Resolving the cause of recurrent Plasmodium vivax malaria probabilistically

AR Taylor, JA Watson, CS Chu, K Puaprasert… - Nature …, 2019 - nature.com
Relapses arising from dormant liver-stage Plasmodium vivax parasites (hypnozoites) are a
major cause of vivax malaria. However, in endemic areas, a recurrent blood-stage infection …

Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo

AI Adekunle, M Pinkevych, R McGready… - PLoS neglected …, 2015 - journals.plos.org
The dynamics of Plasmodium vivax infection is characterized by reactivation of hypnozoites
at varying time intervals. The relative contribution of new P. vivax infection and reactivation …

Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses

ACR Silvino, GL Costa, FCF Araújo, DB Ascher… - PloS one, 2016 - journals.plos.org
Although Plasmodium vivax relapses are classically associated with hypnozoite activation, it
has been proposed that a proportion of these cases are due to primaquine (PQ) treatment …

Micro-epidemiology and spatial heterogeneity of P. vivax parasitaemia in riverine communities of the Peruvian Amazon: A multilevel analysis

G Carrasco-Escobar, D Gamboa, MC Castro… - Scientific reports, 2017 - nature.com
Malaria has steadily increased in the Peruvian Amazon over the last five years. This study
aimed to determine the parasite prevalence and micro-geographical heterogeneity of …

[HTML][HTML] Plasmodium vivax landscape in Brazil: scenario and challenges

AM Siqueira, O Mesones-Lapouble… - The American journal …, 2016 - ncbi.nlm.nih.gov
Brazil is the largest country of Latin America, with a considerable portion of its territoritory
within the malaria-endemic Amazon region in the North. Furthermore, a considerable portion …

Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse

JT Lin, NJ Hathaway, DL Saunders… - The Journal of …, 2015 - academic.oup.com
Plasmodium vivax infections often recur due to relapse of hypnozoites from the liver. In
malaria-endemic areas, tools to distinguish relapse from reinfection are needed. We applied …

A High Resolution Case Study of a Patient with Recurrent Plasmodium vivax Infections Shows That Relapses Were Caused by Meiotic Siblings

AT Bright, MJ Manary, R Tewhey… - PLoS neglected …, 2014 - journals.plos.org
Plasmodium vivax infects a hundred million people annually and endangers 40% of the
world's population. Unlike Plasmodium falciparum, P. vivax parasites can persist as a …

Plasmodium vivax Diversity and Population Structure across Four Continents

C Koepfli, PT Rodrigues, T Antao… - PLoS neglected …, 2015 - journals.plos.org
Plasmodium vivax is the geographically most widespread human malaria parasite. To
analyze patterns of microsatellite diversity and population structure across countries of …