Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

Rationale: Breast cancer preferentially develops osteolytic bone metastasis, which makes
patients suffer from pain, fractures and spinal cord compression. Accumulating evidences …

Multiple local and systemic factors including inflammation influence bone regeneration.
Several lines of evidence demonstrate that macrophages contribute to the immunological …

The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …

With an increasing aging society, China is the world's fastest growing markets for oral
implants. Compared with traditional oral implants, immediate implants cause marginal bone …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Bone diseases including osteoarthritis, osteoporosis, and bone tumors are becoming severe
threats to public health. Bone-targeted biomaterials-based strategies could improve …

Extracellular vesicles (EVs) mediate cell-to-cell communication via the transfer of
biomolecules locally and systemically between organs. It has been elucidated that the …

In the skeletal system, inflammation is closely associated with many skeletal disorders,
including periprosthetic osteolysis (bone loss around orthopedic implants), osteoporosis …