In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Adenylate/uridylate-rich elements (AREs) are found in the 3′ untranslated region (UTR) of
many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription …

Memories of fearful events can last a lifetime. The prelimbic (PL) cortex, a subregion of
prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have …

BONE density achieved in early adulthood is the major determinant of risk of osteoporotic
fracture. Up to 60% of women1, 2 suffer osteoporotic fractures as a result of low bone …

An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay
rates influence gene expression. mRNA stability influences gene expression in virtually all …

For all but a few mRNAs, the dynamics of metabolism are unknown. Here, we developed an
experimental and analytical framework for examining these dynamics for mRNAs from …

The inflammatory response plays out over time in a reproducible and organized way after an
initiating stimulus. Here we show that genes activated in cultured mouse fibroblasts in …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors belonging to the nuclear receptor superfamily. PPARα is highly expressed in liver …