Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

Metadynamics is a powerful technique for enhancing sampling in molecular dynamics
simulations and reconstructing the free‐energy surface as a function of few selected …

We created nanometer-scale transmembrane channels in lipid bilayers by means of self-
assembled DNA-based nanostructures. Scaffolded DNA origami was used to create a stem …

Researchers, clinicians and governments all recognize antimicrobial resistance as a serious
and growing threat worldwide. New antimicrobials are urgently needed, especially for …

Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a
worldwide health problem. The continuous dissemination of 'multidrug-resistant'(MDR) …

To date most antibiotics are targeted at intracellular processes, and must be able to
penetrate the bacterial cell envelope. In particular, the outer membrane of gram-negative …

Gram-negative bacteria are responsible for a large proportion of antibiotic-resistant bacterial
diseases. These bacteria have a complex cell envelope that comprises an outer membrane …

Antibiotics have been overused and misused for preventive and therapeutic purposes.
Specifically, antibiotics are frequently used as growth promoters for improving productivity …

Gram-negative bacteria depend on their cell membranes for survival and environmental
adaptation. They contain two membranes, one of which is the outer membrane (OM), which …

Connexin channels are known to be permeable to a variety of cytoplasmic molecules. The
first observation of second messenger junctional permeability, made∼ 30 years ago …