Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

Serotonin type 7 receptors (5-HT7) are expressed in several brain areas, regulate brain
development, synaptic transmission and plasticity, and therefore are involved in various …

Serotonergic mechanisms play a central role in migraine pathology. However, the region-
specific effects of serotonin (5-HT) mediated via multiple types of receptors in the nociceptive …

The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists
exist, remains the least understood serotonin receptor. A single commercial antagonist, SB …

Objectives: The purpose was to examine central inhibitory mechanisms involved in
analgesia produced by wheel running. Methods: C57/Black6 mice were given access to …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Simple Summary Fiber pathways that descend from the brain to the spinal cord drive motor
behavior and modulate incoming sensory signals and the capacity to change (plasticity). A …

5‐hydroxytryptamine (5‐HT; serotonin) is traditionally considered as a key mediator
implicated in migraine. Multiple 5‐HT receptor subtypes contribute to a variety of region …

Patients with chronic pain often develop comorbid depressive symptoms, which makes the
pain symptoms more complicated and refractory. However, the underlying mechanisms are …

Descending control of nociception (DCN; also known as conditioned pain modulation [CPM],
the behavioral correlate of diffuse noxious inhibitory controls) is the phenomenon whereby …