Food intake, energy expenditure and body adiposity are homeostatically regulated. Central
and peripheral signals communicate information about the current state of energy balance to …

The migrating motor complex (MMC) is a cyclic, recurring motility pattern that occurs in the
stomach and small bowel during fasting; it is interrupted by feeding. The MMC is present in …

Ghrelin is a stomach hormone that acts as an endogenous ligand of orphan G-protein-
coupled receptor. Ghrelin is a 28-amino acid peptide existing in two major forms: n-octanoyl …

GPR39 is an orphan member of the ghrelin receptor family that recently was suggested to be
the receptor for obestatin, a peptide derived from the ghrelin precursor. Here, we compare …

Obesity is one of the greatest public health challenges of the 21st century with 1.6 billion
adults currently classified as being overweight and 400 million as obese. Obesity is causally …

Zhang et al.(Research Articles, 11 November 2005, p. 996) reported that obestatin, a
peptide derived from the ghrelin precursor, activated the orphan G protein–coupled receptor …

Administration of ghrelin, an endogenous ligand for the GH secretagogue receptor 1a
(GHSR 1a), induces potent stimulating effects on GH secretion and food intake. However …

Enteroendocrine cells of the gastrointestinal tract act as a luminal surveillance system
responding to either the presence or absence of food in the gut lumen. Collectively, their …

Numerous peptides released from endocrine cells in the intestinal mucosa were established
early on to be involved in the physiological regulation of food intake with a prominent role in …

Obestatin and ghrelin are two peptides derived from the same prohormone. It is well
established that ghrelin is produced by endocrine cells in the gastric mucosa. However, the …