Our understanding of the pathophysiology of obesity remains at best incomplete despite a
century of research. During this time, two alternative perspectives have helped shape …

Anorexia nervosa (AN) is classically defined as a condition in which an abnormally low body
weight is associated with an intense fear of gaining weight and distorted cognitions …

Food cues during fasting elicit Pavlovian conditioning to adapt for anticipated food intake.
However, whether the olfactory system is involved in metabolic adaptations remains elusive …

Hypothalamic glucose sensing enables an organism to match energy expenditure and food
intake to circulating levels of glucose, the main energy source of the brain. Here, we …

The mechanisms underlying the association between chronic psychological stress,
development of metabolic syndrome (MetS), and behavioral impairment in obesity are …

Ferroptosis requires not only the accumulation of iron ions, but also changes in many
ferroptosis-related regulators, including a decrease in GPX4 and inhibition of SLC7A11 for …

Despite enormous global efforts within clinical research and medical practice to reduce
cardiovascular disease (s)(CVD), it still remains the leading cause of death worldwide. While …

This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

The maintenance of mitochondrial activity in hypothalamic neurons is determinant to the
control of energy homeostasis in mammals. Disturbs in the mitochondrial proteostasis can …

Elevated levels of oxidative stress and neuronal inflammation in the hypothalamus or ventral
midbrain, respectively, represent common denominators for obesity and Parkinson's …