The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
Broad-spectrum anti-biofilm peptide that targets a cellular stress response
C De la Fuente-Núñez, F Reffuveille, EF Haney… - PLoS …, 2014 - journals.plos.org
Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …
Coordination of microbial metabolism
Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …
integrates environmental conditions into intracellular signals. The underlying regulatory …
Genome-wide effects on Escherichia coli transcription from ppGpp binding to its two sites on RNA polymerase
P Sanchez-Vazquez, CN Dewey… - Proceedings of the …, 2019 - National Acad Sciences
The second messenger nucleotide ppGpp dramatically alters gene expression in bacteria to
adjust cellular metabolism to nutrient availability. ppGpp binds to two sites on RNA …
adjust cellular metabolism to nutrient availability. ppGpp binds to two sites on RNA …
Transcriptional responses to ppGpp and DksA
RL Gourse, AY Chen, S Gopalkrishnan… - Annual review of …, 2018 - annualreviews.org
The stringent response to nutrient deprivation is a stress response found throughout the
bacterial domain of life. Although first described in proteobacteria for matching ribosome …
bacterial domain of life. Although first described in proteobacteria for matching ribosome …
MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis
Critical to the bacterial stringent response is the rapid relocation of resources from
proliferation toward stress survival through the respective accumulation and degradation of …
proliferation toward stress survival through the respective accumulation and degradation of …
Affinity-based capture and identification of protein effectors of the growth regulator ppGpp
The nucleotide ppGpp is a highly conserved regulatory molecule in bacteria that helps tune
growth rate to nutrient availability. Despite decades of study, how ppGpp regulates growth …
growth rate to nutrient availability. Despite decades of study, how ppGpp regulates growth …
(p) ppGpp: magic modulators of bacterial physiology and metabolism
W Steinchen, V Zegarra, G Bange - Frontiers in Microbiology, 2020 - frontiersin.org
When bacteria experience growth-limiting environmental conditions, the synthesis of the
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy
Summary Chaperone-mediated autophagy (CMA), a selective form of degradation of
cytosolic proteins in lysosomes, contributes to maintenance of proteostasis and to the …
cytosolic proteins in lysosomes, contributes to maintenance of proteostasis and to the …