CD4+ T cells in cancer
Cancer immunology and immunotherapy are driving forces of research and development in
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
oncology, mostly focusing on CD8+ T cells and the tumor microenvironment. Recent …
Tumor-draining lymph nodes: At the crossroads of metastasis and immunity
Early engagement of the lymphatic system by solid tumors in peripheral, nonlymphoid
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
tissues is a clinical hallmark of cancer and often forecasts poor prognosis. The significance …
A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response
“Stem-like” TCF1+ CD8+ T (TSL) cells are necessary for long-term maintenance of T cell
responses and the efficacy of immunotherapy, but, as tumors contain signals that should …
responses and the efficacy of immunotherapy, but, as tumors contain signals that should …
Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
CD4 T-cell exhaustion: does it exist and what are its roles in cancer?
In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
Modulating Treg stability to improve cancer immunotherapy
JH Kang, R Zappasodi - Trends in cancer, 2023 - cell.com
Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …
[HTML][HTML] Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates
with poor prognosis and is associated with local immunosuppression, which can be partly …
with poor prognosis and is associated with local immunosuppression, which can be partly …
[HTML][HTML] The role of CD4 T cells in rejection of solid tumors
L Poncette, J Bluhm, T Blankenstein - Current Opinion in Immunology, 2022 - Elsevier
Highlights•Versatility of CD4 T cells enables different attack modes towards cancer
cells.•Cooperation of CD4 and CD8 T cells renders anti-tumor responses most …
cells.•Cooperation of CD4 and CD8 T cells renders anti-tumor responses most …
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies
Anti-CTLA-4 antibodies have successfully elicited durable tumor regression in the clinic;
however, long-term benefit is limited to a subset of patients for select cancer indications. The …
however, long-term benefit is limited to a subset of patients for select cancer indications. The …
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4+ TH1 cell response
A Sutra Del Galy, S Menegatti, J Fuentealba… - Science …, 2021 - science.org
Although CD8+ T cells undergo autonomous clonal proliferation after antigen stimulation in
vivo, the expansion of activated CD4+ T cells is limited by intrinsic factors that are poorly …
vivo, the expansion of activated CD4+ T cells is limited by intrinsic factors that are poorly …