The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

Truncating variants in TTN (TTNtvs) are the most common known cause of nonischemic
dilated cardiomyopathy (DCM), but how TTNtvs cause disease has remained controversial …

The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …

Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …

Myocardial passive stiffness is crucial for the heart's pump function and is determined by
mechanical elements, including the extracellular matrix and cytoskeletal filaments; however …

The discovery of the giant protein titin, also known as connectin, dates almost half a century
back. In this review, I recapitulate major advances in the discovery of the titin filaments and …

BACKGROUND: Increasing cardiomyocyte contraction during myocardial stretch serves as
the basis for the Frank-Starling mechanism in the heart. However, it remains unclear how …

Heart failure (HF) and cancer are the leading causes of death worldwide and accumulating
evidence demonstrates that HF and cancer affect one another in a bidirectional way …

编码肌联蛋白（ titin） 的TTN 基因突变是扩张型心肌病（ dilated cardiomyopathy， DCM）
遗传病因中最常见的突变类型。 该文就当前国内外对TTN 基因突变导致儿童DCM …