Transcription factors and transporters in zinc homeostasis: lessons learned from fungi

DJ Eide - Critical reviews in biochemistry and molecular biology, 2020 - Taylor & Francis
Zinc is an essential nutrient for all organisms because this metal serves as a critical
structural or catalytic cofactor for many proteins. These zinc-dependent proteins are …

Zinc sensing and regulation in yeast model systems

S Wilson, AJ Bird - Archives of biochemistry and biophysics, 2016 - Elsevier
The Zap1 transcription factor of Saccharomyces cerevisiae and the Loz1 transcription factor
of Schizosaccharomyces pombe both play a central role in zinc homeostasis by controlling …

[HTML][HTML] The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast

ME Corkins, S Wilson, JC Cocuron, AP Alonso… - Journal of Biological …, 2017 - ASBMB
Glycolysis and the pentose phosphate pathway both play a central role in the degradation of
glucose in all domains of life. Another metabolic route that can facilitate glucose breakdown …

[HTML][HTML] Zinc transporters belonging to the Cation Diffusion Facilitator (CDF) family have complementary roles in transporting zinc out of the cytosol

S Choi, YM Hu, ME Corkins, AE Palmer, AJ Bird - PLoS genetics, 2018 - journals.plos.org
Zinc is an essential trace element that is required for the function of a large number of
proteins. As these zinc-binding proteins are found within the cytosol and organelles, all …

Cellular sensing and transport of metal ions: implications in micronutrient homeostasis

AJ Bird - The Journal of nutritional biochemistry, 2015 - Elsevier
Micronutrients include the transition metal ions zinc, copper and iron. These metals are
essential for life as they serve as cofactors for many different proteins. On the other hand …

A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis

N Dietrich, DL Schneider, K Kornfeld - Nucleic acids research, 2017 - academic.oup.com
The essential element zinc plays critical roles in biology. High zinc homeostasis
mechanisms are beginning to be defined in animals, but low zinc homeostasis is poorly …

[HTML][HTML] The nuclear receptor HIZR-1 uses zinc as a ligand to mediate homeostasis in response to high zinc

K Warnhoff, HC Roh, Z Kocsisova, CH Tan… - PLoS …, 2017 - journals.plos.org
Nuclear receptors were originally defined as endocrine sensors in humans, leading to the
identification of the nuclear receptor superfamily. Despite intensive efforts, most nuclear …

A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans

HC Roh, I Dimitrov, K Deshmukh, G Zhao… - Nucleic acids …, 2015 - academic.oup.com
Zinc is essential for biological systems, and aberrant zinc metabolism is implicated in a
broad range of human diseases. To maintain homeostasis in response to fluctuating levels …

Mechanisms of copper and zinc homeostasis in pathogenic black fungi

MG Silva-Bailão, KLP da Silva, LRB Dos Anjos… - Fungal biology, 2018 - Elsevier
Black fungi comprise a diverse group of melanized microorganisms, many of which are able
to infect humans. One of the recognized diseases that arise with black fungi infection is …

Zinc homeostasis in Schizosaccharomyces pombe

R Yao, R Li, Y Huang - Archives of Microbiology, 2023 - Springer
Most metal ions such as iron, calcium, zinc, or copper are essential for all eukaryotes.
Organisms must maintain homeostasis of these metal ions because excess or deficiency of …