Simple Summary Colorectal cancer (CRC) is very common throughout the world. Despite an
improved outcome with the current treatment regimen, a huge number of patients relapse …

Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …

Background Accumulating studies have revealed that aberrant expression of circular RNAs
(circRNAs) is widely involved in the tumorigenesis and progression of malignant cancers …

Widespread changes to DNA methylation and chromatin are well documented in cancer, but
the fate of higher-order chromosomal structure remains obscure. Here we integrated …

Understanding cancer metastasis at the proteoform level is crucial for discovering previously
unknown protein biomarkers for cancer diagnosis and drug development. We present the …

Colorectal cancer (CRC) is a serious disease that affects millions of people throughout the
world, despite considerable advances in therapy. The formation of colorectal adenomas and …

Colorectal cancer (CRC), a leading cause of cancer-related mortalities globally, results from
the accumulation of multiple genetic and epigenetic alterations in the normal colonic and …

An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play
important roles in diverse cellular processes, including proliferation, apoptosis, migration …

Background The pan-immune-inflammation value (PIV) has been reported as a novel
prognostic biomarker in multiple malignancies. The aim of this study is to investigate the …