The buccal route is considered patient friendly due to its non-invasive nature and ease of
administration. Such delivery route has been used as an alternative for the delivery of drugs …

Biologic products are large molecules such as proteins, peptides, nucleic acids, etc., which
have already produced many new drugs for clinical use in the last decades. Due to the …

Buccal delivery of small and large molecules is an attractive route of administration that has
been studied extensively over the past few decades. This route bypasses first-pass …

The main route of administration for drug products is the oral route, yet biologics are initially
developed as injectables due to their limited stability through the gastrointestinal tract and …

Highlights•The buccal route has been exploited for selected potent small
molecules.•Research to achieve buccal insulin delivery is based on avoiding the …

Monoclonal antibodies (mAbs) are extensively employed for disease diagnosis and
treatment because of their high homogeneity and antigen specificity. In recent years …

Owing to their biological diversity, high potency, good tolerability, low immunogenicity, site-
specific activity, and great efficacy, macromolecular drugs (ie, proteins and peptides …

The purpose of the present examination was to prepare fluconazole (FZ)-loaded solid lipid
nanoparticles (FZ-loaded SLNs) for a buccal drug delivery system using the Box-Behnken …

To develop an effective, convenient and stable mucosal vaccine against hepatitis B virus
(HBV), the mannose-PEG-cholesterol/lipid A-liposomes (MLLs) loaded with HBsAg were …

The buccal mucosa provides an alternative route of drug delivery that can be more
beneficial compared to other administration routes. Although numerous studies and reviews …