DNA damage, DNA repair, and alcohol toxicity—a review

PJ Brooks - Alcoholism: Clinical and Experimental Research, 1997 - Wiley Online Library
Alcohol (ethanol) is clearly a toxic substance when consumed in excess. Chronic alcohol
abuse results in a variety of pathological effects, including damage to the liver and brain, as …

Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction …

RP Vetreno, JM Hall, LM Savage - Neurobiology of learning and memory, 2011 - Elsevier
Chronic alcoholism is associated with impaired cognitive functioning. Over 75% of autopsied
chronic alcoholics have significant brain damage and over 50% of detoxified alcoholics …

Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy

KG Baker, AJ Harding, GM Halliday, JJ Kril, CG Harper - Neuroscience, 1999 - Elsevier
This study examines the effect of chronic alcohol consumption on the human cerebellum
using operational criteria for case selection [Caine D. et al.(1997) J. Neurol. Neurosurg …

Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema‐based mechanism

MA Collins, J Zou, EJ Neafsey - The FASEB Journal, 1998 - Wiley Online Library
Adult rats intubated with a single dose of ethanol (alcohol;∼ 5 g/kg) for 5 to 10 successive
days incur neurodegeneration in the entorhinal cortex, dentate gyrus, and olfactory bulbs …

[HTML][HTML] Mechanisms of ethanol-induced degeneration in the developing, mature, and aging cerebellum

P Jaatinen, J Rintala - The Cerebellum, 2008 - Springer
The adverse effects of acute and chronic ethanol exposure on cerebellar functions have
been acknowledged for decades, in terms of impaired control of movement and balance. In …

The neuroimmune system–where aging and excess alcohol intersect

ER Carlson, SP Guerin, K Nixon, LK Fonken - Alcohol, 2023 - Elsevier
As the percentage of the global population over age 65 grows, and with it a subpopulation of
individuals with alcohol use disorder (AUD), understanding the effect of alcohol on the aged …

[HTML][HTML] Cerebellum and Aging: Update and Challenges

CL McElroy, B Wang, H Zhang, K Jin - Aging and Disease, 2024 - pmc.ncbi.nlm.nih.gov
The cerebellum plays a vital role in the aging process. With the aging of the cerebellum,
there is a decline in balance and motor function, particularly fine motor skills, and an …

Structural changes in the hippocampal formation after long‐term alcohol consumption and withdrawal in the rat

MM Paula‐Barbosa, F Brandao, MD Madeira… - …, 1993 - Wiley Online Library
The effects of long‐term alcohol consumption and withdrawal upon the structure of the rat
hippocampal formation were studied by applying morphometric methods to material …

Granule cell loss and dendritic regrowth in the hippocampal dentate gyrus of the rat after chronic alcohol consumption

M Ame, HBM Uylings, M Paula-Barbosa - Brain research, 1988 - Elsevier
The effects of chronic alcohol consumption (CAC) on the relative number of dentate gyrus
granule cells and their dendritic trees, were studied in animals fed alcohol for 6, 12 and 18 …

The Immp2l mutation causes age‐dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment

C Liu, X Li, B Lu - Aging Cell, 2016 - Wiley Online Library
Reactive oxygen species are implicated in age‐associated neurodegeneration, although
direct in vivo evidence is lacking. We recently showed that mice with a mutation in the Inner …