Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Fibrinogen is an abundant protein synthesized in the liver, present in human blood plasma
at concentrations ranging from 1.5-4 g/L in healthy individuals with a normal half-life of 3-5 …

Bleeding and thrombosis in critically ill infants and children is a vexing clinical problem.
Despite the relatively low incidence of bleeding and thrombosis in the overall pediatric …

BACKGROUND: Infants undergoing cardiac surgery are at risk for bleeding and massive
transfusion due to an immature coagulation system, complex surgeries, and …

The formation of a fibrin clot matrix plays a critical role in promoting hemostasis and wound
healing. Fibrin dynamics can become disadvantageous in the formation of aberrant …

Background Thrombosis in the neonatal population is rare, but increasing. Its incidence and
management are not well understood. Objectives To investigate the incidence, associated …

Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen,
characterized by increased sialic acid, a greater negative charge, and decreased activity …

Background Thrombogenicity is a known complication of COVID‐19, resulting from SARS‐
CoV‐2 infection, with significant effects on morbidity and mortality. Objective We aimed to …

BACKGROUND: Recombinant factor VIIa (rFVIIa) is routinely used as an off-label hemostatic
agent in children undergoing cardiac surgery. Despite evidence that rFVIIa use is associated …

Excessive bleeding following pediatric cardiopulmonary bypass is associated with
increased morbidity and mortality, both from the effects of hemorrhage and the therapies …