The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer

M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - ASPET
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

[HTML][HTML] Triglyceride-rich lipoproteins and cytosolic lipid droplets in enterocytes: key players in intestinal physiology and metabolic disorders

S Demignot, F Beilstein, E Morel - Biochimie, 2014 - Elsevier
During the post-prandial phase, intestinal triglyceride-rich lipoproteins (TRL) ie chylomicrons
are the main contributors to the serum lipid level, which is linked to coronary artery diseases …

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

H Lanaya, A Natarajan, K Komposch, L Li… - Nature cell …, 2014 - nature.com
Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …

Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism

A Zani, M Cananzi, F Fascetti-Leon, G Lauriti, VV Smith… - Gut, 2014 - gut.bmj.com
Objective Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity
and mortality in neonates and alternative strategies are needed. Stem cells have become a …

Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro

W Wang, T Xia, X Yu - Inflammation Research, 2015 - Springer
Aims and objective Wogonin has multiple pharmacological effects, including anti-
inflammatory effects. Here, we hypothesize that wogonin can protect intestinal barrier …

Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch

DJ Hackam, M Good, CP Sodhi - Seminars in pediatric surgery, 2013 - Elsevier
Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal causes in
premature infants, and its overall survival has not improved in the past three decades. While …

Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia

Q Xia, Q Hu, H Wang, H Yang, F Gao, H Ren… - Cell death & …, 2015 - nature.com
Neuroinflammation is a striking hallmark of amyotrophic lateral sclerosis (ALS) and other
neurodegenerative disorders. Previous studies have shown the contribution of glial cells …

Tyrosine phosphorylation in Toll-like receptor signaling

S Chattopadhyay, GC Sen - Cytokine & growth factor reviews, 2014 - Elsevier
There is a wealth of knowledge about how different Ser/Thr protein kinases participate in
Toll-like receptor (TLR) signaling. In many cases, we know the identities of the Ser/Thr …

TNF-α induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6

Y Yuan, D Ding, N Zhang, Z Xia, J Wang, H Yang… - Cell Cycle, 2018 - Taylor & Francis
Necrotizing enterocolitis (NEC) is a potentially fatal illness in premature neonates. Tumor
necrosis factor-α (TNF-α) and autophagy are associated with the pathogenesis of NEC. This …

Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury

R Di Cagno, P Filannino, O Vincentini, V Cantatore… - Nutrients, 2019 - mdpi.com
P. oleracea L. contains high level of nutrients and biologically active compounds. Recently,
lactic fermentation has been proposed as a biotechnological option to enrich the profile of …