The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - ASPET
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
[HTML][HTML] Triglyceride-rich lipoproteins and cytosolic lipid droplets in enterocytes: key players in intestinal physiology and metabolic disorders
S Demignot, F Beilstein, E Morel - Biochimie, 2014 - Elsevier
During the post-prandial phase, intestinal triglyceride-rich lipoproteins (TRL) ie chylomicrons
are the main contributors to the serum lipid level, which is linked to coronary artery diseases …
are the main contributors to the serum lipid level, which is linked to coronary artery diseases …
EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
H Lanaya, A Natarajan, K Komposch, L Li… - Nature cell …, 2014 - nature.com
Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …
poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic …
Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism
Objective Necrotising enterocolitis (NEC) remains one of the primary causes of morbidity
and mortality in neonates and alternative strategies are needed. Stem cells have become a …
and mortality in neonates and alternative strategies are needed. Stem cells have become a …
Wogonin suppresses inflammatory response and maintains intestinal barrier function via TLR4-MyD88-TAK1-mediated NF-κB pathway in vitro
W Wang, T Xia, X Yu - Inflammation Research, 2015 - Springer
Aims and objective Wogonin has multiple pharmacological effects, including anti-
inflammatory effects. Here, we hypothesize that wogonin can protect intestinal barrier …
inflammatory effects. Here, we hypothesize that wogonin can protect intestinal barrier …
Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch
Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal causes in
premature infants, and its overall survival has not improved in the past three decades. While …
premature infants, and its overall survival has not improved in the past three decades. While …
Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia
Q Xia, Q Hu, H Wang, H Yang, F Gao, H Ren… - Cell death & …, 2015 - nature.com
Neuroinflammation is a striking hallmark of amyotrophic lateral sclerosis (ALS) and other
neurodegenerative disorders. Previous studies have shown the contribution of glial cells …
neurodegenerative disorders. Previous studies have shown the contribution of glial cells …
Tyrosine phosphorylation in Toll-like receptor signaling
S Chattopadhyay, GC Sen - Cytokine & growth factor reviews, 2014 - Elsevier
There is a wealth of knowledge about how different Ser/Thr protein kinases participate in
Toll-like receptor (TLR) signaling. In many cases, we know the identities of the Ser/Thr …
Toll-like receptor (TLR) signaling. In many cases, we know the identities of the Ser/Thr …
TNF-α induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6
Y Yuan, D Ding, N Zhang, Z Xia, J Wang, H Yang… - Cell Cycle, 2018 - Taylor & Francis
Necrotizing enterocolitis (NEC) is a potentially fatal illness in premature neonates. Tumor
necrosis factor-α (TNF-α) and autophagy are associated with the pathogenesis of NEC. This …
necrosis factor-α (TNF-α) and autophagy are associated with the pathogenesis of NEC. This …
Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury
P. oleracea L. contains high level of nutrients and biologically active compounds. Recently,
lactic fermentation has been proposed as a biotechnological option to enrich the profile of …
lactic fermentation has been proposed as a biotechnological option to enrich the profile of …