Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

[HTML][HTML] Methamphetamine-induced neuronal damage: neurotoxicity and neuroinflammation

B Kim, J Yun, B Park - Biomolecules & therapeutics, 2020 - ncbi.nlm.nih.gov
Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely
abused drugs worldwide. The continuous use of METH eventually leads to drug addiction …

Microglia in neuroimmunopharmacology and drug addiction

H Li, LR Watkins, X Wang - Molecular Psychiatry, 2024 - nature.com
Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

THC and CBD: villain versus hero? Insights into adolescent exposure

N Pintori, F Caria, MA De Luca, C Miliano - International Journal of …, 2023 - mdpi.com
Cannabis is the most used drug of abuse worldwide. It is well established that the most
abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and …

[HTML][HTML] Herbal bioactives in treatment of inflammation: An overview

M Gupta, N Singh, M Gulati, R Gupta… - South African Journal of …, 2021 - Elsevier
Background Inflammation, an important event of cellular defensive system, can be triggered
by a variety of factors such as pathogens, allergens, damaged cells and toxic compounds …

[HTML][HTML] Lipopolysaccharide induced altered signaling pathways in various neurological disorders

S Singh, K Sahu, C Singh, A Singh - Naunyn-Schmiedeberg's Archives of …, 2022 - Springer
Neuroinflammation is defined as an inflammatory response within the brain or spinal cord,
whereas the brain's innate immune system is triggered by various inflammatory challenges …

Cancer Initiation, Progression and Resistance: Are Phytocannabinoids from Cannabis sativa L. Promising Compounds?

E Nigro, M Formato, G Crescente, A Daniele - Molecules, 2021 - mdpi.com
Cannabis sativa L. is a source of over 150 active compounds known as phytocannabinoids
that are receiving renewed interest due to their diverse pharmacologic activities. Indeed …

The common denominators of Parkinson's disease pathogenesis and methamphetamine abuse

B Vincent, M Shukla - Current Neuropharmacology, 2024 - benthamdirect.com
The pervasiveness and mortality associated with methamphetamine abuse have doubled
during the past decade, suggesting a possible worldwide substance use crisis. Epitomizing …

Cannabidiol reduces short-and long-term high glutamate release after severe traumatic brain injury and improves functional recovery

C Santiago-Castañeda, S Huerta de la Cruz… - Pharmaceutics, 2022 - mdpi.com
This study aimed to determine if orally administered cannabidiol (CBD) lessens the cortical
over-release of glutamate induced by a severe traumatic brain injury (TBI) and facilitates …

[HTML][HTML] Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis

X Zhang, X Gao, X Yi, H Yu, M Shao, Y Li, X Shen - Materials Today Bio, 2024 - Elsevier
The pathogenesis of ulcerative colitis (UC) is closely related to severe inflammation,
damaged colonic mucosal barrier, increased oxidative stress and intestinal ecological …