Mammalian SWI/SNF chromatin remodeling complexes move and evict nucleosomes at
gene promoters and enhancers to modulate DNA access. Although SWI/SNF subunits are …

Genetic models suggested that SMARCA5 was required for DNA-templated events including
transcription, DNA replication, and DNA repair. We engineered a degron tag into the …

Activation of regeneration upon tissue damages requires the activation of many
developmental genes responsible for cell proliferation, migration, differentiation, and tissue …

Totipotency represents the highest developmental potency. By definition, totipotent stem
cells are capable of giving rise to all embryonic and extraembryonic cell types. In …

Abstract Polycomb repressive complex 1 (PRC1) comprises two different complexes: CBX-
containing canonical PRC1 (cPRC1) and RYBP/YAF2-containing variant PRC1 (vPRC1) …

Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved
protein, is known to play a critical role in chromatin structure. Post-translational modifications …

The three-dimensional genome structure organized by CTCF is required for development.
Clinically identified mutations in CTCF have been linked to adverse developmental …

Background Nucleosome remodeling factors regulate the occupancy and positioning of
nucleosomes genome-wide through ATP-driven DNA translocation. While many …

One bottleneck in understanding the principles of 3D chromatin structures is caused by the
paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its …

Rationale: Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of
the diaphragm and lung hypoplasia. The pathophysiology of lung defects in CDH is poorly …