Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

BACKGROUND Blood and lymphatic vessel networks form two arms of the vertebrate
cardiovascular system that play complementary roles in body homeostasis maintenance and …

Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to
facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs …

The influx and efflux of cells and antigens to and from the draining lymph nodes largely take
place through the subcapsular, cortical and medullary sinus systems. Recent analyses in …

Recent discoveries of novel functions and diverse origins of lymphatic vessels have
drastically changed our view of lymphatic vasculature. Traditionally regarded as passive …

Secondary lymphoid organs are integral to initiation and execution of adaptive immune
responses. These organs provide a setting for interactions between antigen-specific …

Ectopic lymphoid structures form in a wide range of inflammatory conditions, including
infection, autoimmune disease, and cancer. In the context of infection, this response can be …

Lymphatic vessels form a critical component in the regulation of human health and disease.
While their functional significance is increasingly being recognized, the comprehensive …

Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue
integrity in the intestine. Yet, which signals are sensed and what receptors control ILC3 …