Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

Analyses of steroid receptors are important for understanding molecular details of
transcriptional control, as well as providing insight as to how an individual transacting factor …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

NF-KB is a nuclear protein, found only in cells that transcribe immunoglobulin light chain
genes, that interacts with a defined site in the K immunoglobulin enhancer. This protein can …

Low-stringency hybridization with human glucocorticoid receptor (hGR) complementary
DNA was used to isolate a new gene encoding a predicted 107-kilodalton polypeptide …

Identification of complementary DNAs encoding the human glucocorticoid receptor predicts
two protein forms, of 777 (α) and 742 (β) amino acids, which differ at their carboxy termini …

Contemporary views on the structure and function of chromatin are presented and the
history of the development of these ideas as well as the nature of the nucleic acid and …

Gene regulation by steroid hormones has been a traditional field of research for biochemical
endocrinology since the discovery of puff induction by ecdysone in giant chromosomes of …

The mechanism by which the estrogen receptor and other steroid hormone receptors
regulate gene expression in eukaryotic cells is not well understood. In this study, a …

Steroid hormones (SHs) are lipophilic molecules derived from cholesterol and synthesized
in the adrenal cortex (glucocorticoids, mineralocorticoids, and adrenal androgens), the …