The biomechanical signature of loss of consciousness: computational modelling of elite athlete head injuries

KA Zimmerman, J Cournoyer, H Lai, SB Snider… - Brain, 2023 - academic.oup.com
Sports related head injuries can cause transient neurological events including loss of
consciousness and dystonic posturing. However, it is unknown why head impacts that …

The benefits of exercise for outcome improvement following traumatic brain injury: Evidence, pitfalls and future perspectives

Y Zhang, Z Huang, H Xia, J Xiong, X Ma, C Liu - Experimental Neurology, 2022 - Elsevier
Traumatic brain injury (TBI), also known as a silent epidemic, is currently a substantial public
health problem worldwide. Given the increased energy demands following brain injury …

[HTML][HTML] Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Detecting axonal injury in individual patients after traumatic brain injury

AE Jolly, M Bălăeţ, A Azor, D Friedland, S Sandrone… - Brain, 2021 - academic.oup.com
Poor outcomes after traumatic brain injury (TBI) are common yet remain difficult to predict.
Diffuse axonal injury is important for outcomes, but its assessment remains limited in the …

Distinct patterns of structural damage underlie working memory and reasoning deficits after traumatic brain injury

AE Jolly, GT Scott, DJ Sharp, AH Hampshire - Brain, 2020 - academic.oup.com
It is well established that chronic cognitive problems after traumatic brain injury relate to
diffuse axonal injury and the consequent widespread disruption of brain connectivity …

[HTML][HTML] Neuroradiological changes following single or repetitive mild TBI

P Kulkarni, TR Morrison, X Cai, S Iriah… - Frontiers in systems …, 2019 - frontiersin.org
Objectives To test the hypothesis that there are differences in neuroradiological measures
between single and repeated mild traumatic brain injury using multimodal MRI. Methods A …

Stratifying drug treatment of cognitive impairments after traumatic brain injury using neuroimaging

PO Jenkins, S De Simoni, NJ Bourke, J Fleminger… - Brain, 2019 - academic.oup.com
Cognitive impairment is common following traumatic brain injury. Dopaminergic drugs can
enhance cognition after traumatic brain injury, but individual responses are highly variable …

N6-methyladenosine RNA modification: a promising regulator in central nervous system injury

Q Wang, Y Liang, X Luo, Y Liu, X Zhang, L Gao - Experimental Neurology, 2021 - Elsevier
In addition to DNA methylation, reversible epigenetic modification occurring in RNA has
been discovered recently. The most abundant type of RNA methylation is N6 …

Paths to successful translation of new therapies for severe traumatic brain injury in the golden age of traumatic brain injury research: a Pittsburgh vision

PM Kochanek, TC Jackson, RM Jha… - Journal of …, 2020 - liebertpub.com
New neuroprotective therapies for severe traumatic brain injury (TBI) have not translated
from pre-clinical to clinical success. Numerous explanations have been suggested in both …

[HTML][HTML] Approaches to monitor circuit disruption after traumatic brain injury: frontiers in preclinical research

G Krishna, JA Beitchman, CE Bromberg… - International journal of …, 2020 - mdpi.com
Mild traumatic brain injury (TBI) often results in pathophysiological damage that can manifest
as both acute and chronic neurological deficits. In an attempt to repair and reconnect …