Genome-scale metabolic modeling of the human microbiome in the era of personalized medicine
The human microbiome plays an important role in human health and disease. Meta-omics
analyses provide indispensable data for linking changes in microbiome composition and …
analyses provide indispensable data for linking changes in microbiome composition and …
[HTML][HTML] Multiscale analysis of independent Alzheimer's cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus
Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …
and progression of Alzheimer's disease (AD) although definitive evidence has not been …
Genetic regulation of vertebrate forebrain development by homeobox genes
Forebrain development in vertebrates is regulated by transcription factors encoded by
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
homeobox, bHLH and forkhead gene families throughout the progressive and overlapping …
Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer's disease
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
Local genetic correlation quantifies the genetic similarity of complex traits in specific
genomic regions. However, accurate estimation of local genetic correlation remains …
genomic regions. However, accurate estimation of local genetic correlation remains …
A single-cell genomic atlas for maturation of the human cerebellum during early childhood
Inflammation early in life is a clinically established risk factor for autism spectrum disorders
and schizophrenia, yet the impact of inflammation on human brain development is poorly …
and schizophrenia, yet the impact of inflammation on human brain development is poorly …
Gene biomarker discovery at different stages of Alzheimer using gene co-expression network approach
Alzheimer's disease (AD) is a chronic neurodegenerative disorder. It is the most common
type of dementia that has remained as an incurable disease in the world, which destroys the …
type of dementia that has remained as an incurable disease in the world, which destroys the …
Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to huntington's disease mutations
S Malaiya, M Cortes-Gutierrez, BR Herb… - Journal of …, 2021 - Soc Neuroscience
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
a trinucleotide expansion in exon 1 of the huntingtin (HTT) gene. Cell death in HD occurs …
Recapitulation of perturbed striatal gene expression dynamics of donors' brains with ventral forebrain organoids derived from the same individuals with schizophrenia
T Sawada, AR Barbosa, B Araujo… - American Journal of …, 2024 - psychiatryonline.org
Objective: Schizophrenia is a brain disorder that originates during neurodevelopment and
has complex genetic and environmental etiologies. Despite decades of clinical evidence of …
has complex genetic and environmental etiologies. Despite decades of clinical evidence of …
Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy
Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder
characterized by tau pathology in neurons and glial cells. Transcriptional regulation has …
characterized by tau pathology in neurons and glial cells. Transcriptional regulation has …