Synovial proliferation, neovascularization and leukocyte extravasation transform the
normally acellular synovium into an invasive tumour-like'pannus'. The highly dysregulated …

The Notch signaling plays a key role in cell differentiation, survival, and proliferation through
diverse mechanisms. Notch signaling is also involved in vasculogenesis and angiogenesis …

Objectives This study examines the relationship between synovial hypoxia and cellular
bioenergetics with synovial inflammation. Methods Primary rheumatoid arthritis synovial …

Significance: Epithelial–mesenchymal transition (EMT) is emerging as a driving force in
tumor progression, enabling cancer cells to evade their “homeland” and to colonize remote …

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a
critical role in many physiological processes including cellular differentiation, cell cycle …

Objective To examine the effect of hypoxia on Signal Transducer and Activator of
Transcription 3 (STAT3)-induced pro-inflammatory pathways in rheumatoid arthritis (RA) …

Gastric carcinoma is one of the most common malignancies and a lethal cancer in the world.
Notch signaling and transcription factors STAT3 (signal transducer and activator of …

Defining the signaling network that controls reactive astrogliosis may provide novel
treatment targets for patients with diverse CNS injuries and pathologies. We report that the …

In the neurovascular unit, the neuronal and vascular systems communicate with each other.
O 2 and nutrients, reaching endothelial cells (ECs) through the blood stream, spread into …

Notch signaling is an evolutionarily ancient, highly conserved pathway important for
deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion …