The Mediator complex as a master regulator of transcription by RNA polymerase II
WF Richter, S Nayak, J Iwasa, DJ Taatjes - Nature Reviews Molecular …, 2022 - nature.com
The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …
Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins
We have conducted a detailed transcriptomic, proteomic and phosphoproteomic analysis of
CDK8 and its paralog CDK19, alternative enzymatic components of the kinase module …
CDK8 and its paralog CDK19, alternative enzymatic components of the kinase module …
[HTML][HTML] XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation
L Richart, ML Picod-Chedotel, M Wassef, M Macario… - Cell, 2022 - cell.com
X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis,
promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is …
promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is …
The Mediator kinase module: an interface between cell signaling and transcription
O Luyties, DJ Taatjes - Trends in biochemical sciences, 2022 - cell.com
The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo
X Ding, AC Sharko, MSJ McDermott… - Proceedings of the …, 2022 - National Acad Sciences
Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are
treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase …
treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase …
ZBTB12 is a molecular barrier to dedifferentiation in human pluripotent stem cells
Abstract Development is generally viewed as one-way traffic of cell state transition from
primitive to developmentally advanced states. However, molecular mechanisms that ensure …
primitive to developmentally advanced states. However, molecular mechanisms that ensure …
The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II
S Osman, E Mohammad, M Lidschreiber… - Journal of Biological …, 2021 - ASBMB
The Cdk8 kinase module (CKM) is a dissociable part of the coactivator complex mediator,
which regulates gene transcription by RNA polymerase II. The CKM has both negative and …
which regulates gene transcription by RNA polymerase II. The CKM has both negative and …
Chromatin and epigenetic rearrangements in embryonic stem cell fate transitions
L Sun, X Fu, G Ma, AP Hutchins - Frontiers in cell and developmental …, 2021 - frontiersin.org
A major event in embryonic development is the rearrangement of epigenetic information as
the somatic genome is reprogrammed for a new round of organismal development …
the somatic genome is reprogrammed for a new round of organismal development …