KRAP is required for diffuse and punctate IP3-mediated Ca2+ liberation and determines the number of functional IP3R channels within clusters

I Vorontsova, JT Lock, I Parker - Cell Calcium, 2022 - Elsevier
KRas-induced actin-interacting protein (KRAP) has been identified as crucial for the
appropriate localization and functioning of the inositol trisphosphate receptors (IP 3 Rs) that …

IP3 receptors: An “elementary” journey from structure to signals

HA Smith, NB Thillaiappan, AM Rossi - Cell Calcium, 2023 - Elsevier
Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) are large tetrameric channels
which sit mostly in the membrane of the endoplasmic reticulum (ER) and mediate Ca 2+ …

An integrate-and-fire approach to Ca2+ signaling. Part II: Cumulative refractoriness

L Ramlow, M Falcke, B Lindner - Biophysical Journal, 2023 - cell.com
Abstract Inositol 1, 4, 5-trisphosphate-induced Ca 2+ signaling is a second messenger
system used by almost all eukaryotic cells. The agonist concentration stimulating Ca 2+ …

[HTML][HTML] An efficient reduced-lattice model of IP3R for probing Ca2+ dynamics

H Gao, L Liu, A Zaikin, S Chen - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
Numerous cellular processes are regulated by Ca 2+ signals, and the endoplasmic
reticulum (ER) membrane's inositol triphosphate receptor (IP 3 R) is critical for modulating …