Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural product …, 2022 - pubs.rsc.org
Covering: 2020 This review covers the literature published in 2020 for marine natural
products (MNPs), with 757 citations (747 for the period January to December 2020) referring …

[HTML][HTML] Scorpion venom peptides: Molecular diversity, structural characteristics, and therapeutic use from channelopathies to viral infections and cancers

Z Xia, D He, Y Wu, HF Kwok, Z Cao - Pharmacological Research, 2023 - Elsevier
Animal venom is an important evolutionary innovation in nature. As one of the most
representative animal venoms, scorpion venom contains an extremely diverse set of …

Nemertean, brachiopod, and phoronid neuropeptidomics reveals ancestral spiralian signaling systems

D Thiel, LA Yanez-Guerra… - Molecular Biology …, 2021 - academic.oup.com
Neuropeptides are diverse signaling molecules in animals commonly acting through G-
protein coupled receptors (GPCRs). Neuropeptides and their receptors underwent extensive …

Sea anemone Membrane Attack Complex/Perforin Superfamily demonstrates an evolutionary transitional state between venomous and developmental functions

JM Surm, M Landau… - Molecular Biology …, 2024 - academic.oup.com
Gene duplication is a major force driving evolutionary innovation. A classic example is
generating new animal toxins via duplication of physiological protein-encoding genes and …

Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family

LM Ashwood, KA Elnahriry, ZK Stewart, T Shafee… - BMC biology, 2023 - Springer
Abstract Background The ShK toxin from Stichodactyla helianthus has established the
therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin …

[PDF][PDF] Reconstructing the origins of the somatostatin and allatostatin-C signaling systems using the accelerated evolution of biodiverse cone snail toxins

TL Koch, IBL Ramiro, P Flórez Salcedo… - Molecular Biology …, 2022 - academic.oup.com
Somatostatin and its related peptides (SSRPs) form an important family of hormones with
diverse physiological roles. The ubiquitous presence of SSRPs in vertebrates and several …

New Insights Into Biomphalysin Gene Family Diversification in the Vector Snail Biomphalaria glabrata

S Pinaud, G Tetreau, P Poteaux, R Galinier… - Frontiers in …, 2021 - frontiersin.org
Aerolysins initially characterized as virulence factors in bacteria are increasingly found in
massive genome and transcriptome sequencing data from metazoans. Horizontal gene …

[PDF][PDF] Evolution, expression patterns, and distribution of novel ribbon worm predatory and defensive toxins

A Verdes, S Taboada, BR Hamilton… - Molecular Biology …, 2022 - academic.oup.com
Ribbon worms are active predators that use an eversible proboscis to inject venom into their
prey and defend themselves with toxic epidermal secretions. Previous work on nemertean …

Insights into how development and life-history dynamics shape the evolution of venom

JM Surm, Y Moran - EvoDevo, 2021 - Springer
Venomous animals are a striking example of the convergent evolution of a complex trait.
These animals have independently evolved an apparatus that synthesizes, stores, and …

Proteotransciptomics of the Most Popular Host Sea Anemone Entacmaea quadricolor Reveals Not All Toxin Genes Expressed by Tentacles Are Recruited into Its …

CM Hoepner, ZK Stewart, R Qiao, EK Fobert, PJ Prentis… - Toxins, 2024 - mdpi.com
While the unique symbiotic relationship between anemonefishes and sea anemones is
iconic, it is still not fully understood how anemonefishes can withstand and thrive within the …