Pathogenic enteric viruses are a major cause of morbidity and mortality, particularly among
children in developing countries. The host response to enteric viruses occurs primarily within …

A cornerstone of the global initiative to eradicate polio is the widespread use of live and
inactivated poliovirus vaccines in extensive public health campaigns designed to prevent …

Understanding humoral immune responses to SARS-CoV-2 infection will play a critical role
in the development of vaccines and antibody-based interventions. We report systemic and …

Background A longitudinal study was performed to determine the breadth, kinetics, and
correlations of systemic and mucosal antibody responses to severe acute respiratory …

The impact of intestinal microbiota on mucosal antibody response to the polio vaccine is
poorly understood. We examined changes in vaccine-induced intestinal mucosal immunity …

Eradication of poliomyelitis globally is constrained by fecal shedding of live polioviruses,
both wild-type and vaccine-derived strains, into the environment. Although inactivated polio …

Infections take their greatest toll in early life necessitating robust approaches to protect the
very young. Here, we review the rationale, current state, and future research directions for …

Background Sabin inactivated and bivalent oral poliovirus vaccine (sIPV, bOPV) were
commonly used in China since 2016. We conducted an open-label, randomised, controlled …

Enterotoxin-based adjuvants including cholera toxin and heat-labile toxin (LT) are powerful
manipulators of mucosal immunity; however, past clinical trials identified unacceptable …

For more than 20 years, the World Health Organization Western Pacific Region (WPR) has
been polio-free. However, two current challenges are still polio-related. First, around half of …