[HTML][HTML] Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases

L Li, C Acioglu, RF Heary, S Elkabes - Brain, behavior, and immunity, 2021 - Elsevier
Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction

EC Kugler, J Greenwood… - Frontiers in Cell and …, 2021 - frontiersin.org
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

The circadian regulation of food intake

E Challet - Nature Reviews Endocrinology, 2019 - nature.com
Feeding, which is essential for all animals, is regulated by homeostatic mechanisms. In
addition, food consumption is temporally coordinated by the brain over the circadian (~ 24 h) …

Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

N Marina, IN Christie, A Korsak, M Doronin… - Nature …, 2020 - nature.com
Astrocytes provide neurons with essential metabolic and structural support, modulate
neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to …

[HTML][HTML] Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations

EA Turovsky, VV Golovicheva… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Mesenchymal stromal cells (MSC) are widely recognized as potential effectors in
neuroprotective therapy. The protective properties of MSC were considered to be associated …

Foundations and implications of astrocyte heterogeneity during brain development and disease

AL Schober, LE Wicki-Stordeur, KK Murai… - Trends in …, 2022 - cell.com
Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent
technological advances have revealed unprecedented levels of astrocyte diversity …

Insulin regulates neurovascular coupling through astrocytes

AM Fernandez, L Martinez-Rachadell… - Proceedings of the …, 2022 - National Acad Sciences
Mice with insulin receptor (IR)–deficient astrocytes (GFAP-IR knockout [KO] mice) show
blunted responses to insulin and reduced brain glucose uptake, whereas IR-deficient …

The role of glia in the physiology and pharmacology of glucagon‐like peptide‐1: implications for obesity, diabetes, neurodegeneration and glaucoma

QN Cui, LM Stein, SM Fortin… - British Journal of …, 2022 - Wiley Online Library
The medical applications of glucagon‐like peptide‐1 receptor (GLP‐1R) agonists is
evergrowing in scope, highlighting the urgent need for a comprehensive understanding of …

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

SM Fortin, RK Lipsky, R Lhamo, J Chen… - Science translational …, 2020 - science.org
The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is approved for the
treatment of obesity; however, there is still much to be learned regarding the neuronal sites …

The astrocytic Na+‐HCO3 cotransporter, NBCe1, is dispensable for respiratory chemosensitivity

K Li, EC Gonye, RL Stornetta, CB Bayliss… - The Journal of …, 2023 - Wiley Online Library
The interoceptive homeostatic mechanism that controls breathing, blood gases and acid‐
base balance in response to changes in CO2/H+ is exquisitely sensitive, with convergent …