The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Aptamers are single-stranded DNA or RNA molecules capable of tightly binding to specific
targets. These functional nucleic acids are obtained by an in vitro Darwinian evolution …

Membrane proteins on the cell surface perform a myriad of biological functions; however,
ligand discovery for membrane proteins is highly challenging, because a natural cellular …

Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize
analytes with extraordinary target selectivity and affinity. Despite their promising properties …

Covalent aptamers are novel biochemical tools for fast and selective transfer of labels to
target proteins. Equipped with cleavable electrophiles, these nucleic acid probes enable the …

Conspectus Conjugation of DNA to proteins is increasingly used in academia and industry
to provide proteins with tags for identification or handles for hybridization to other DNA …

Disease-related biomarkers are objectively measurable molecular signatures of
physiological status that can serve as disease indicators or drug targets in clinical diagnosis …

Currently, functional single-stranded oligonucleotide probes, termed aptamers, generated
by an iterative technology, Systematic Evolution of Ligands by Exponential Enrichment …

Identification of biomarkers is essential for diagnosis, targeted therapy and prognosis
evaluation of diseases, especially cancers. Currently, the number of ideal clinical …

Oligonucleotide (ON) therapeutics are emerging as a new generation of medicine with
tremendous potential, but their clinical translation is hampered by inferior stability and short …