The microtubule cytoskeleton: An old validated target for novel therapeutic drugs
L Lafanechère - Frontiers in Pharmacology, 2022 - frontiersin.org
Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …
However, because they also target non-cancerous cells, their administration leads to …
Coumarins derived from natural methoxystilbene as oxidative stress-related disease alleviators: Synthesis and in vitro-in silico study
YF Mustafa - Journal of Molecular Structure, 2024 - Elsevier
Abstract 3, 4, 5-Trimethoxy-3′-hydroxy-4′-methoxystilbene (TMHMS) is an anticancer
natural stilbene that targets tubulin polymerization. According to research, oxidative stress …
natural stilbene that targets tubulin polymerization. According to research, oxidative stress …
Combretastatin A4-based coumarins: synthesis, anticancer, oxidative stress-relieving, anti-inflammatory, biosafety, and in silico analysis
YF Mustafa - Chemical Papers, 2024 - Springer
A potent natural combretastatin, combretastatin A-4 (COMA4) targets the condylon active
pocket to produce anticancer effects. Studies on inflammation and oxidative stress have …
pocket to produce anticancer effects. Studies on inflammation and oxidative stress have …
Structural Changes, Biological Consequences, and Repurposing of Colchicine Site Ligands
F Montecinos, DL Sackett - Biomolecules, 2023 - mdpi.com
Microtubule-targeting agents (MTAs) bind to one of several distinct sites in the tubulin dimer,
the subunit of microtubules. The binding affinities of MTAs may vary by several orders of …
the subunit of microtubules. The binding affinities of MTAs may vary by several orders of …