Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
SR Meshnick, TE Taylor… - Microbiological …, 1996 - Am Soc Microbiol
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a
promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs …
promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs …
Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents
D Chaturvedi, A Goswami, PP Saikia… - Chemical Society …, 2010 - pubs.rsc.org
In this tutorial review, an effort towards presentation of a comprehensive account of the
recent developments on various kinds of artemisinin derivatives including artemisinin …
recent developments on various kinds of artemisinin derivatives including artemisinin …
Current perspectives on the mechanism of action of artemisinins
J Golenser, JH Waknine, M Krugliak, NH Hunt… - International journal for …, 2006 - Elsevier
Artemisinin derivatives are the most recent single drugs approved and introduced for public
antimalarial treatment. Although their recommended use is for treatment of Plasmodium …
antimalarial treatment. Although their recommended use is for treatment of Plasmodium …
Artemisinins: mechanisms of action and potential for resistance
Artemisinins form the most important class of antimalarial currently available, particularly
because they are effective against parasites resistant to almost all the other classes. Their …
because they are effective against parasites resistant to almost all the other classes. Their …
Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism (s) of action
JN Cumming, P Ploypradith, GH Posner - Advances in pharmacology, 1996 - Elsevier
Publisher Summary Malaria is one of the most deadly infectious diseases known to
mankind. The species of Plasmodium that cause malaria can develop resistance to …
mankind. The species of Plasmodium that cause malaria can develop resistance to …
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements
RK Haynes - Current topics in medicinal chemistry, 2006 - ingentaconnect.com
The artemisinin derivatives, dihydroartemisinin (DHA), artesunate, atemether and arteether,
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …
Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon …
GH Posner, CH Oh, D Wang, L Gerena… - Journal of medicinal …, 1994 - ACS Publications
Because malaria parasites are rapidly developing mul-tidrug resistance to the most common
chemotherapeutic alkaloidal drugs, 1-2 interest in the antimalarial properties of …
chemotherapeutic alkaloidal drugs, 1-2 interest in the antimalarial properties of …
Natural products in the “marketplace”: interfacing synthesis and biology
BJ Huffman, RA Shenvi - Journal of the American Chemical …, 2019 - ACS Publications
Drugs are discovered through the biological screening of collections of compounds,
followed by optimization toward functional end points. The properties of screening …
followed by optimization toward functional end points. The properties of screening …
Antischistosomal activity of artemisinin derivatives in vivo and in patients
MEM Saeed, S Krishna, HJ Greten, PG Kremsner… - Pharmacological …, 2016 - Elsevier
Schistosomiasis is a helminthic disease affecting more than 200 million people in the tropics
as well as returning travellers. Treatment mainly relies on a single drug, praziquantel …
as well as returning travellers. Treatment mainly relies on a single drug, praziquantel …
Structure-activity relationships of sesquiterpene lactones
TJ Schmidt - Studies in natural products chemistry, 2006 - Elsevier
Sesquiterpene lactones (STLs) are one of the largest biogenetically homogenous groups of
natural products known. Currently, the Dictionary of Natural Products holds a total of over …
natural products known. Currently, the Dictionary of Natural Products holds a total of over …