Artemisinin and its derivatives are endoperoxide-containing compounds which represent a
promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs …

In this tutorial review, an effort towards presentation of a comprehensive account of the
recent developments on various kinds of artemisinin derivatives including artemisinin …

Artemisinin derivatives are the most recent single drugs approved and introduced for public
antimalarial treatment. Although their recommended use is for treatment of Plasmodium …

Artemisinins form the most important class of antimalarial currently available, particularly
because they are effective against parasites resistant to almost all the other classes. Their …

Publisher Summary Malaria is one of the most deadly infectious diseases known to
mankind. The species of Plasmodium that cause malaria can develop resistance to …

The artemisinin derivatives, dihydroartemisinin (DHA), artesunate, atemether and arteether,
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …

Because malaria parasites are rapidly developing mul-tidrug resistance to the most common
chemotherapeutic alkaloidal drugs, 1-2 interest in the antimalarial properties of …

Drugs are discovered through the biological screening of collections of compounds,
followed by optimization toward functional end points. The properties of screening …

Schistosomiasis is a helminthic disease affecting more than 200 million people in the tropics
as well as returning travellers. Treatment mainly relies on a single drug, praziquantel …

Sesquiterpene lactones (STLs) are one of the largest biogenetically homogenous groups of
natural products known. Currently, the Dictionary of Natural Products holds a total of over …