High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …

Plants have adapted to tolerate and survive constantly changing environmental conditions
by reprogramming gene expression The dynamics of the contribution of alternative splicing …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

Alternative splicing of pre-mRNAs is a major contributor to both proteomic diversity and
control of gene expression levels. Splicing is tightly regulated in different tissues and …

We present GraphProt, a computational framework for learning sequence-and structure-
binding preferences of RNA-binding proteins (RBPs) from high-throughput experimental …

The highly abundant N6-methyladenosine (m6A) RNA modification affects most aspects of
mRNA function, yet the precise function of the rarer 5-methylcytidine (m5C) remains largely …

Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried
out by the spliceosome, along with other auxiliary factors. In general, research in splicing …

Alternative splicing is a widespread means of increasing protein diversity and regulating
gene expression in eukaryotes. Much progress has been made in understanding the …